Sabrina P. Trudo
21st Century Endowed Chair in Human Environmental Sciences
Dale Bumpers College of Agricultural, Food & Life Sciences
(THES)-AFLS-Human Environ Science
We focus on plant foods and cancer prevention:
- Dietary modulation of biotransformation enzymes and carcinogen metabolism
- Development of dietary biomarkers
- Gene – diet interactions: both nutrigenomic (animal models) and nutrigenetic (in humans)
- Diet effects on colonic miRNA expression, cancer stem cells
- Comparison of the effects from intact vegetable feeding versus their purified putative chemopreventive compounds
Expanding interest into obesity:
- Role of bioactive plant compounds in decreasing obesity-mediated cancer risk
- Role of plant foods and their constituents in childhood obesity prevention
- Virtual reality as a means to prevent childhood obesity.
PhD - Nutritional Science, University of Washington, Seattle, WA
BS - Dietetics, Brigham Young University, Provo, UT
Kim JK, Gallaher DD, Chen Chi, Yao D, Trudo SP. (2015) Apiaceous vegetable consumption decreases PhIP-induced DNA adducts and increases methylated PhIP metabolites in the urine metabolome in rats. J Nutr 145:442-451.
Trudo SP, Gallaher DD. (2015) Meat and colorectal cancer: associations and issues. Curr Nutr Rep 4:33-39.
Navarro SL, Schwarz Y, Song X, Wang CY, Chen C, Trudo SP, Kristal AR, Kratz M, Eaton DL, Lampe JW. (2014) Cruciferous vegetables had variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults. J Nutr 144:1850-1857.
Ainslie-Waldman CE, Simpkins SW, Upadhyaya P, Carmella SG, Hecht SS, Trudo SP. (2013) Contamination of deconjugation enzymes derived from Helix pomatia with the plant bioactive compounds 3,3’-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen. Food Chem Toxicol 62:188-193.
Larson ED, Groskreutz SR, Harmes DC, Gibbs-Hall IC, Trudo SP, Allen RC,Rutan SC, Stoll DR. (2013) Development of Selective Comprehensive Two-Dimensional Liquid Chromatography with Parallel First Dimension Sampling and Second Dimension Separation – Application to the Quantitative Analysis of Multiple Furanocoumarins in Apiaceous Vegetables. Anal Bioanal Chem 405:4639-4653.
Gallaher DG, Trudo SP. (2013) Nutrition and colon cancer. In: Coulston AM, Boushey CJ, editors. Nutrition in the prevention and treatment of disease. San Diego, CA: Elsevier Academic Press.
Gallaher CM, Gallaher DD, Peterson S. (2012) Development and validation of a spectrophotometric method for simple quantification of total glucosinolates in cruciferous vegetables. J Agric Food Chem 60:1358-1362.
Kang AY, Young LR, Dingfelder CS, Peterson S. (2011) Effects of furanocoumarins from apiaceous vegetables on the catalytic activity of recombinant human cytochrome P-450 1A2. Protein J 30:447-456.
Kim JK, Choi SJ, Bae H, Kim CR, Cho HY, Kim YJ, Lim ST, Kim CJ, Kim HK, Peterson S, Shin DH. (2011) Effects of methoxsalen from Poncirus trifoliata on acetylcholinesterase and trimethyltin-induced learning and memory impairment. Biosci Biotechnol Biochem 75:1984-1989.
Kim JK, Choi SJ, Cho HY, Kim YJ, Lim ST, Kim CJ, Kim EK, Kim HK, Peterson S, Shin DH. (2011) Ipomoea batatas attenuates amyloid beta peptide (Aβ)-induced neurotoxicity in ICR mice. J Med Food 14:1-6.
Kim JK, Choi SJ, Cho HY, Hwang HJ, Kim YJ, Lim ST, Kim EK, Peterson S, Shin DH. (2010) Protective effects of kaempferol (3,4’,5,7-tetrahydroxyflavone) against amyloid beta peptide (Aβ)-induced neurotoxicity on ICR mice. Biosci Biotechnol Biochem 74:397-401.
Peterson S, Yuan JM, Koh WP, Sun CL, Wang R, Turesky RT, Yu MC. (2010) Coffee intake and risk of colorectal cancer among Chinese in Singapore: the Singapore Chinese Health Study. Nutr Cancer 62:21-9.
Navarro SL, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW. (2009) Modulation of human serum glutathione S-transferase-α concentration by cruciferous vegetable supplementation in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes. Cancer Epidemiol Biomarkers Prev 18:2974-2978.
Peterson S, Schwarz Y, Li SS, Li L, King IB, Chen C, Potter JD, Lampe JW. (2009) CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial. Cancer Epidemiol Biomarkers Prev 18:3118-3125.
Navarro SL, Peterson S, Chen C, Makar KW, Schwarz Y, King IB, Li SS, Li L, Kestin M, Potter JD, Lampe JW. (2009) Cruciferous vegetable feeding alters UGT1A1 activity: diet- and genotype-dependent changes in serum bilirubin concentrations in a controlled feeding trial. Cancer Prev Res 2:345-52.
Turesky RJ, Yuan JM, Wang R, Peterson S, Yu MC. (2007) Tobacco smoking and urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, China. Cancer Epidemiol Biomarkers Prev 16:1554-60.
Peterson S, Lampe JW, Gross-Steinmeyer K, Bammler TK, Eaton DL. (2006) Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food Chem Toxicol 44:1474-1484.
Peterson S, Lampe JW, Bigler J, Horner NK, Potter JD. (2005) Cruciferae interact with UGT1A1*28 polymorphism to determine serum bilirubin levels in humans J Nutr 135:1051-1055.
Peterson S, Lampe JW, Eaton DL. (2004) Genetic susceptibility to dietary carcinogens. In: Watson D, editor. Pesticides, veterinary and other chemical residues in food. Cambridge, UK: Woodhead Publishing Ltd.
Lampe JW, Peterson S. (2002) Brassica, biotransformation and cancer risk: genetic polymorphisms alter the preventive effects of cruciferous vegetables. J Nutr 132: 2991-2994.
21ST Century Endowed Chair in Human Environmental Sciences, University of Arkansas